ABSTRACT
Angiogenesis is the formation of new blood vessels which is a key part of tumor growth and spread. New blood vessels convey nutrients to the cancer, fueling their abnormal growth and metastasis. The first successful antiangiogenic inhibitor interferon alfa2a has been used for the treatment of pulmonary hemangiomatosis in 1989. Tumors cannot grow or spread without the formation of new blood vessels, so researchers have begun studying ‘antiangiogenic agents’ by counting severe side-effects for radiation, chemotherapy as well as other ways of management of cancer. Advantages of antiangiogenic therapy are that this class of drugs show only mild side effects, non toxic to most healthy cells and not develop any resistance over a long period of therapy. Unfortunately no suitable natural or synthetic antiangiogenic agent has been developed still now. Therefore this review gives an insight that the natural sources might be the key target for the development of more potent, less toxic and cheapest antiangiogenic agents.